| Date | | ...#... | | Title | | Writer.............. | | Director |
| Sept 16, 2008 | | 501 | | Dying Changes Everything | | Eli Attie | | Deran Sarafian |
| Wilson returns from his leave after Amber's death and tells House he is resigning so House walks out on his patient (the assistant to a feminist consultant) to guilt Wilson into staying.
|
| Sept 23, 2008 | | 502 | | Not Cancer | | David Shore & Lawrence Kaplow | | David Straiton |
| House hires a private investigator who not only spies on aspects of the case and Wilson but also changes a patient's medication.
|
| Sept. 20, 2008 | | 503 | | Adverse Events | | Carol Green & Dustin Paddock | | Andrew Bernstein |
| The team treats an artist who paints what he thinks is a realistic portrait but it is terribly distorted as House makes known what the PI finds out about the team members.
|
| Oct. 14, 2008 | | 504 | | Birthmarks | | Doris Egan & David Foster | | David Platt |
| House treats a patient back from China while avoiding his father's funeral until Wilson kidnaps him.
|
| Oct. 21, 2008 | | 505 | | Lucky Thirteen | | Liz Friedman & Sara Hess
| | Greg Yaitanes |
| A woman Thirteen has taken home has a seizure after sex. House fires Thirteen but later hires her back.
|
| Oct. 28, 2008 | | 506 | | Joy | | David Hoselton | | Deran Sarafian |
| Cuddy has made arrangements to adopt a baby when Becca gives birth. When they meet Cuddy notices a rash on her arm. Meanwhile, House's team treats a man with blackouts and hallucinations.
|
| Nov. 11, 2008 | | 507 | | The Itch | | Peter Blake | | Greg Yaitanes |
| Cameron brings House the case of a man who hasn't left his house in seven years so they have to diagnose and treat him in his home.
|
| Nov. 18, 2008 | | 508 | | Emancipation | | Pamela Davis & Leonard Dick | | Jim Hayman |
| House and his team try to figure out what caused the seizure of an emancipated minor while Foreman deals with a four year old boy with something no one else can figure out.
|
| Nov. 25, 2008 | | 509 | | Last Resort | | Matthew V. Lewis & Eli Attie | | Katie Jacobs |
| House and Thirteen and others are taken hostage by a man who has something no one can figure out. Thirteen is used to make sure House isn't giving him anything dangerous.
|
| Dec. 2, 2008 | | 510 | | Let Them Eat Cake | | Russel Friend & Garrett Lerner | | Deran Sarafian |
| A thirty year-old fitness "guru" collapses. Foreman's trial includes Thirteen.
|
| Dec. 9, 2008 | | 511 | | Joy to the World | | Peter Blake | | David Straiton |
| The team treats a 16 year old who is overweight and often bullied, Cuddy deduces that she gave birth recently and goes out to find the baby.
|
| Jan 19, 2009 | | 512 | | Painless | | Thomas Moran & Eli Attie | | Andrew Bernstein |
| The team treats a man who is in such pain that he tries to commit suicide. House relates to the situation.
|
| Jan 26, 2009 | | 513 | | Big Baby | | David Foster & Lawrence Kaplow | | Deran Sarafian |
| A teacher of special needs children has a high level of patience and House considers that one of her symptoms. Cameron sits in for Cuddy as Cuddy deals with the baby she is now fostering.
|
| Feb 2, 2009 | | 514 | | The Greater Good | | Sara Hess | | Lesli Linka Glatter |
| A famous doctor, who has become a chef, diagnoses herself as she collapses, the team try to figure out why she has what she has. Meanwhile Foreman changed Thirteen from the placebo and it has caused complications.
|
| Feb 16, 2009 | | 515 | | Unfaithful | | David Hoselton | | Greg Yaitanes |
| A priest, who has lost his faith but keeps working for the homeless, has a couple of drinks one cold night and sees a crucified Jesus.
|
| Feb 23, 2009 | | 516 | | The Softer Side | | Liz Friedman | | Deran Sarafian |
| Jackson, who has both male and female DNA (genetic mosaicism) but whose parents have raised him as a boy without telling him about the problem in his genes, collapses with severe abdominal pain after a basketball game. House tries methadone and becomes nicer.
|
| Mar 9, 2009 | | 517 | | The Social Contract | | Doris Egan | | Andrew Bernstein |
| Nick Greenwald all of a sudden starts saying whatever he is thinking and then gets a nosebleed and collapses. Wilson has discovered where his long lost, homeless brother is.
|
| Mar 16, 2009 | | 518 | | Here Kitty | | Peter Blake | | Juan J. Campanello |
| The head of nursing at an old age home believes a cat there can predict when someone will die by sleeping next to them and cat slept next to her. Taub is having money problems and thinking of leaving the team.
|
| Mar 30, 2009 | | 519 | | Locked In | | Russel Friend & Garrett Lerner & David Foster | | Dan Attias |
| House has a motorcycle accident and ends up in an ER with a patient the doctor thinks is brain dead but that House thinks is suffering locked-in syndrome.
|
| Apr 6, 2009 | | 520 | | Simple Explanation | | Leonard Dick | | Greg Yaitanes |
| The wife of a dying man suddenly collapses. And the team finds Kutner dead of an apparent suicide.
|
| Apr 13, 2009 | | 521 | | Saviors | | Eli Attie & Thomas L. Moran | | Matthew Penn |
| An environmental activist collapses, Cameron gets involved to keep from giving Chase a chance to propose, which she thinks he might do just in response to Kutner's death.
|
| Apr 27, 2009 | | 522 | | House Divided | | Matthew V. Lewis & Liz Friedman | | Greg Yaitanes |
| Deaf 14 year old suddenly hears explosions in his head. Chase and Cameron plan their wedding and House plans Chase's bachelor party.
|
| Apr 27, 2009 | | 523 | | Under My Skin | | Pamela Davis & Lawrence Kaplow
| | David Straiton |
| Ballerina collapses during rehearsals and House decides he needs medical help for his hallucinations --- he has been seeing Amber for several episodes. He thinks he has asked Cuddy to help him detox.
|
| May 11, 2009 | | 524 | | Both Sides Now | | Doris Egan | | Greg Yaitanes |
| To get rid of seizures a young man had surgery to separate the left and right halves of his brain but now has problems. And House thinks he and Cuddy had sex and when he realizes it was another hallucination, House finally agrees to be hospitalized.
|